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CLINICAL TRIAL PARTICIPANT PAYMENTS

Simplify clinical trial payments without compromising voluntariness.

Deliver approved patient stipends, visit reimbursements, and participation payments with less delay and less administrative friction. TruCentive gives sponsors and sites flexible delivery, participant choice, claim-aware reminders, and transparent reconciliation.

No credit card required. Build and send de-identified payment samples before you commit.

TruCentive clinical trial payments illustration
THE EXECUTIVE CASE

Clinical trial payments are part of trial design—not a back-office task.

Fair compensation recognizes time and burden; reimbursement restores reasonable participation-related expenses. FDA guidance says payment should be just and fair, reviewed by the IRB, described in informed consent, and accrued as the study progresses—not held hostage to completion. A sound operating system makes that approved plan easier for participants and research teams to follow.

$200–$1K

monthly travel burden reported

An NCBI evidence review reports that travel-related participation costs in some studies ranged from roughly $200 to $1,000 per month, depending on distance and trial demands.

4–5%

retention increase observed

One natural experiment in a military clinical trial observed a modest 4%–5% retention increase after reimbursement became available; this is setting-specific evidence.

31.9%

digital incentive value unclaimed

TruCentive reports that 31.9% of digital awards, gifts, and incentives went unclaimed in 2025—value that may never reach its intended recipient.

1M+

payment and reward options

TruCentive offers 1M+ gift card, merchandise, payment, prepaid, and other options for recipient choice.

WHY EVEN SMALL PAYMENTS MATTER

A modest payment can remove a very real barrier.

For a participant, parking, fuel, meals, childcare, connectivity, or time away from work can determine whether a visit is feasible. Even a modest approved payment can acknowledge burden or restore a cost that would otherwise fall on the participant.

Restore out-of-pocket costs

Reimbursement can cover reasonable expenses such as airfare, parking, lodging, mileage, meals, or other approved costs. FDA states that reasonable travel reimbursement does not, by itself, raise undue-influence concerns.

Recognize time and burden

Stipends or compensation recognize time, effort, inconvenience, and burden. Amounts should be just, fair, proportionate, and reviewed for the specific protocol and population.

Pay as participation progresses

Credit should accrue as visits or activities occur. Prorated or milestone-based payments protect the right to withdraw and avoid making the entire amount contingent on completion.

Preserve participant choice

Where the approved plan allows it, offer payment methods that fit participants’ location, access needs, and preferences. Choice should improve usability—not change the study’s risk-benefit assessment.

BUILT FOR THE PARTICIPANT JOURNEY

One approved payment plan. Every trial milestone.

Standardize controls and reconciliation while preserving each protocol’s approved amounts, eligible expenses, visit schedule, withdrawal treatment, payment methods, privacy model, and consent language.

Visit stipends

Deliver approved compensation after scheduled site visits, procedures, interviews, or assessments without maintaining manual gift-card inventories.

Travel & lodging reimbursement

Reimburse approved mileage, airfare, parking, lodging, meals, or other expenses according to sponsor, site, and protocol rules.

Screening & enrollment

Handle approved screening-related expenses or payments consistently, including the documented treatment of screen failures and pre-enrollment travel.

Milestone participation payments

Trigger prorated payments after approved visits, phases, diaries, questionnaires, or other protocol milestones instead of waiting for study completion.

Remote & decentralized activities

Support telehealth visits, ePRO completion, remote interviews, decentralized assessments, and connectivity-related reimbursement where approved.

Longitudinal follow-up

Maintain consistent payment and reminder workflows for extension studies, follow-up assessments, registries, and long-duration participation.

WHY TRUCENTIVE

A better participant experience. A more governable payment operation.

TruCentive combines participant choice with the controls sponsors, CROs, sites, Finance, Procurement, Security, Privacy, and Compliance expect. Build reusable projects, use subject IDs, deliver through multiple channels, automate reminders, and track the who, what, and when of approved payments.

1M+ participant-friendly options

Offer gift cards, direct-payment methods, prepaid options, merchandise, or a curated selection where the approved payment plan permits participant choice.

International and local reach

Support international programs with country-specific options and local merchants. Product availability does not replace local ethics, tax, sanctions, currency, labor, or regulatory review.

Delivery that follows through

Send by email, SMS, both, printed links, or bulk links. Automated reminders stop after claim; post-claim messages can confirm receipt or provide approved next steps.

Privacy-minded visibility

Use subject IDs and data-minimization practices, monitor delivery and claim status, and apply roles and controls. TruCentive describes a HIPAA de-identification capability; each covered entity must validate its own HIPAA obligations, configuration, and agreements.

A BETTER PAYMENT OPERATING MODEL

Compare what Trial Operations and Finance actually get.

Decision factor

Manual or single-card approach

TruCentive Pay as You Go

Unused payment value

May be trapped in purchased cards, retained as provider breakage, or difficult to return to the protocol budget.

Returned to your TruCentive account under Pay as You Go.

Participant options

One card type, physical inventories, or separate vendors by country.

1M+ gift card, payment, prepaid, merchandise, and other options.

Payment operations

Manual purchasing, code inventories, spreadsheets, and one-off participant emails.

Reusable projects, individual or list-based sends, email/SMS, printed delivery, and bulk links.

Visit follow-through

One payment message with manual resend and support work.

Claim-aware reminders, resend or revoke controls, and approved post-claim communication.

Privacy and reconciliation

Payment operations may expose excess identifiers and provide limited closeout visibility.

Subject-ID workflows, roles and controls, claim tracking, reporting, and unclaimed-value visibility.

TruCentive reports 20.5% of clinical-trial compensation went unclaimed in 2022 and reports 31.9% unclaimed across digital incentives in 2025. It says most Pay as You Go customers save 23% after fees. Verify the methodology and current figures before publication; results depend on protocol, payment amount, timing, population, delivery method, and claim period.

FROM APPROVAL TO RECONCILIATION

Operationalize the payment plan the IRB or IEC reviewed.

01

Approve the payment framework

Define reimbursement, compensation, appreciation, and any completion component separately. Document amounts, purpose, schedule, proration, withdrawal treatment, eligible expenses, payment methods, tax handling, and approval requirements for each population and country.

02

Configure visits and milestones

Map every approved visit, activity, expense, and payment milestone. Configure eligibility, recipient identifiers, delivery channels, reminders, expiration, resend or revoke authority, and exception handling.

03

Deliver through approved channels

Deliver only after the applicable approved event or expense verification. Use the minimum participant information necessary and keep clinical data out of the payment workflow wherever possible.

04

Monitor and reconcile

Monitor delivery, claims, failed messages, duplicates, exceptions, partial participation, and unclaimed value. Reconcile against the protocol budget and approved payment schedule without exposing unnecessary clinical information.

QUESTIONS TRIAL LEADERS ASK

Support participation while protecting informed consent.

What is the difference between a stipend and reimbursement?

Reimbursement restores reasonable participation-related expenses. A stipend or compensation recognizes time, effort, inconvenience, or burden. Consent materials and payment records should describe each accurately.

What payment information should the IRB review?

FDA says the IRB should review the amount, method, and timing of payment for fairness and undue influence. The consent document should state all payment information, including the schedule and applicable conditions.

What happens if a participant withdraws?

Payment should accrue as participation progresses and should not be wholly contingent on study completion. The approved plan should explain partial payment, timing, and what happens if the investigator removes a participant.

Does travel reimbursement create undue influence?

FDA does not consider reimbursement for reasonable travel expenses—such as airfare, parking, and lodging—to raise undue-influence concerns by itself. The protocol and IRB still determine what is reasonable and approved.

How should clinical trial payments protect participant privacy?

Minimize identifiers, use approved subject IDs, apply role-based access, and keep clinical information separate from payment operations. HIPAA de-identification requires either Safe Harbor or Expert Determination; risk is reduced, not necessarily zero.

Can one workflow support global trials?

One platform can support multi-country delivery, but the approved amount, method, tax treatment, currency, sanctions screening, privacy terms, consent language, and ethics requirements must be validated for every jurisdiction and site.

MAKE PATIENT-CENTRIC PAYMENTS OPERATIONALLY SIMPLE

Design your clinical trial payment workflow today.

Bring one protocol payment schedule to a TruCentive design session. Leave with a branded sample, mapped visit and reimbursement workflow, and a clearer approach to participant delivery and closeout.

1M+ options · International coverage · Email, SMS & bulk links · Subject-ID workflows · Unclaimed value returned with Pay as You Go